0143 Trait Emotion Reactivity Predicts Change in Negative but Not Positive Affect During Total Sleep Deprivation

Abstract Introduction During laboratory-based, voluntary exposure to total sleep deprivation (TSD), relatively large decreases in positive mood and small increases negative have been observed, with the magnitudes of change varying across individuals. People differ their trait emotion reactivity, i.e., sensitivity emotion-evoking stimuli or events. As higher reactivity is associated greater difficulty regulating emotion, we hypothesized this could moderate changes during TSD. Methods N=96 healthy adults (ages 21-38, 47% female) participated one three 4-day/3-night in-laboratory TSD studies. In each study, after 10h baseline sleep, participants were exposed 38h TSD, followed by recovery sleep. Participants completed Emotion Reactivity Scale (ERS), self-reported affect was assessed every 2-4h wake using Positive Negative Affect Schedule (PANAS). The 11 test bouts shared studies included analyses (day 2: 09:00, 13:00, 21:00, 23:00; day 3: 01:00, 03:00, 05:00, 07:00, 21:00). ratings analyzed linear mixed-effects regression fixed effects bout (categorical), ERS score (continuous), interaction, covariates for sex, age, a random intercept over participants. Results showed expected decrease as function (time awake time day, p< 0.001), smaller, non-significant increase (p=0.17). Higher scores increased (p=0.002), but effect small, floor effect. not significant predictor decreased (p=0.97). Conclusion hypothesized, predicted individual variability unexpectedly it did predict This suggests that measured may be biased toward affect, and/or affective more difficult low arousal state induced Studies inducing (e.g., through stressor) are needed confirm our findings. Support (if any) NIH CA167691, ONR N00014-13-1-0302, CDMRP W81XWH-16-1-0319 W81XWH-20-1-0442.